Citing Research Articles

Here are snippets of collections of researches from different institutions &/or individuals, about Soursop (Graviola or Annona Muricata). We are in no way related to any authors of such works therefore discretion among readers is advised.  

“Until recently, in vitro research indicated that several of the active ingredients (Annonaceous acetogenins) kill malignant cells of 12 different types of cancer including breast, ovarian, colon, prostate, liver, lung, pancreatic and lymphoma.
Originally listed by the National Cancer Institute in the USA in 1976, it was not until 1995 that work gained any momentum.
By 2008 the NCI supported the Purdue research, which confirmed that extracts from Graviola leaves killed cancer cells among six human-cell lines and were especially effective against prostate and pancreatic cancers. Another study showed their effect against lung cancer.
Other studies, this time by the Catholic University in South Korea has shown that the active ingredients have selective cytoxicity comparable with Adriamycin, a drug historically used for breast and colon cancer. A further study published in the Journal of Natural Products claimed Graviola was 10,000 times more effective; a third study from South Korea showed that, unlike Adriamycin, there was no negative activity on healthy cells; whilst a fourth study from Purdue (1997) stated that many cancer cells which survive classic chemotherapy by developing resistance to chemicals, were attacked none-the-less by the Graviola agents.
Dr Jerry McLaughlin, Purdue´s lead researcher says that many cancer cells, over time, develop a P-glycoprotein pump to expel the chemotherapy agent before it can work. However Annona chemicals bypass this and kill the cancer cell. 
All in all, Purdue researchers have found dramatic activity against worms, some viruses, fungi and many cancer cell lines.
Nutrition and Cancer, June 2011, covered research from scientists at Virginia Tech showing that phytochemicals in Graviola could reduce the growth of breast cancer. And in mice given Graviola fruit extract for five weeks there was a ´significant reduction in protein expression in breast cancer tumors. Overall, graviola extract reduced tumour growth by 32 per cent.
In October 2012, Cancer Letter, a team from the Department of Biochemistry and Molecular Biology at theUniversity of Nebraska Medical Center showed that Graviola killed pancreatic cancer cells both in test tubes and in animals and humans.

The researchers showed Graviola inhibits signaling pathways and this led to a decrease in the rate of cancer cell division and growth, also slowing metastases.”


Information not intended to replace the advice of a doctor. We disclaim any liability for the decisions made based on this information.

On anti-cancer properties of Annona Muricata

From a brief review on recent advances in clinical research of Annona Muricata   by Trupti P. Sawant and Dayanand P. Gogle*

Test Materials Concentration Mean Living Retardation IC50
(ug/ml) Absorbance Cells (%)  (%) (ug/ml)
Ethanol Extract A. Muricata 500 0.161 7.71 92.29
250 0.129 2.34 97.66
125 0.141 4.36 95.64 17.149
62.5 0.138 3.8 96.2
31.25 0.457 57.28 42.72
Tamoxifen 50 0.253 0 100
25 0.262 0.19 99.81
12.5 0.889 71.62 28.38 13.38
6.25 1.07 92.29 7.71
3.125 0.167 91.95 8.05

Absorbance value of the parameters obtained from the test was IC50 values, one that produce inhibitory concentrations of cancer cells by 50%. The results showed that extracts of soursop has a relatively higher cytotoxic activity with IC50 value, as documented in this research.



Information not intended to replace the advice of a doctor. We disclaim any liability for the decisions made based on this information.


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